Do you use it in combination with Lightroom? LR processing first?
I do DXO first, so that it could work on the RAW file. I then save as TIFF and finish in LR.
If I need to do something in LR that requires the RAW too, I'd process the RAW in both and then manually blend in PS.
If only saving an edited file in RAW were possible, but alas, by definition, it isn't.