I'm doing LAX-TLV with 6 kids for Pesach, direct in LY Y. done it before, with less kids, but now the older ones are more helpful. Have problems with both kicking in front and standing up and harassing the people behind us, so when we just did LAX-NYC we did:
X X
X X X
X X X
with the two biggest kids in the front and the trouble makers with a parent in back. way there the middle seat was occupied (my kids gave her the aisle) way back it was empty (and somehat wasted on two little kids who were perfectly fine wtih a Y. But it was our best flights with them. The inflight games etc were a huge help.
Now we try to tack on 10 hours.