Hi
SWIM has used ayahuasca and discussed with a number of rabbanim, some of who's names you will be familiar with.
If you would like to speak, send me an email youme2526@gmail.com
It has significant potential for positive results but unfortunately can have some negatives too.
I personally have had some very positive experiences with dmt, as well as with mushrooms.
mushrooms played a big part in bringing me back to a religious life, B"H
For an extremely comprehensive understanding see
https://www.dmt-nexus.me/forum/default.aspx?g=forumIf you want to achieve a transcendental state without the use of chemicals, check out holotropic breathing (grof breathing) you may want to ask a shayla about this too.
Possible problematic that I heard are: koisaim kesamim. ov/yidoini, darchei emori, among other very serious laavin (some chayvei misa skila) however depending on its use and purpose. Look at the Rambam sefer hamitzvos for each of these.
Keep in mind that some of these would apply to cannabis as well, if they apply to dmt.
If you are going to experience this in a clinical setting than this warning would not be so important, but: If you are using smokable or injectable dmt you should be ok, as long as it is extracted and prepared properly and has very minimal impurities.
If you are going to be using oral dmt (ayahuasca, yage) bear in mind that caapi is a reversible Monoamino oxide inhibitor (MAOI) and certainly pharmausca (which uses a pharmaceutical maoi rather than caapi and is not considered reversible) which can have very severe interactions with many psychiatric drugs (and some non-psychiatric ones too, some cardiac drugs) interaction can lead to a possibly fatal hypertensive crisis, which is hard enough but think about going through it while tripping and you anyways feel like you are dying. Your soul floating out of your body, and having your insides turning inside out as you vomit like you never did before from deep in your bowels. your mind gets ripped open and all the experiences you have ever had, as well as everything that has happened since briyas haolam is poured into your mind while seeing all sorts of colors and shapes. It can get pretty intense!!
I would be very happy to discuss further