COVID-19 (Wuhan Novel Coronavirus) Pandemic Master Thread

[PlatinumGuy]

https://twitter.com/robertson_lab/status/1324470959093460992?s=21

[avromie7]

https://twitter.com/robertson_lab/status/1324470959093460992?s=21

English?

[Euclid]

English?

Abstract

SARS-CoV-2 can mutate to evade immunity, with consequences for the efficacy of emerging vaccines and antibody therapeutics. Herein we demonstrate that the immunodominant SARS-CoV-2 spike (S) receptor binding motif (RBM) is the most divergent region of S, and provide epidemiological, clinical, and molecular characterization of a prevalent RBM variant, N439K. We demonstrate that N439K S protein has enhanced binding affinity to the hACE2 receptor, and that N439K virus has similar clinical outcomes and in vitro replication fitness as compared to wild-type. We observed that the N439K mutation resulted in immune escape from a panel of neutralizing monoclonal antibodies, including one in clinical trials, as well as from polyclonal sera from a sizeable fraction of persons recovered from infection. Immune evasion mutations that maintain virulence and fitness such as N439K can emerge within SARS-CoV-2 S, highlighting the need for ongoing molecular surveillance to guide development and usage of vaccines and therapeutics.

[AsherO]

English?

There’s specific data confirming that COVID could mutate in ways that it’ll evade antibodies. Not really actionable by the layperson at this point.

[S209]

@Kobe Bryant Turns out, COVID kills lots of people. I heard that more frum people have died of COVID in Lakewood in the last month than died of all causes in Lakewood the entire 2019 (!!).

Anybody have any idea how I could further verify if those numbers are accurate or not?

ETA: The number obviously sounds completely absurd on its face, as I would presume there are dozens if not hundreds of deaths annually. But how would I find this information?

[Euclid]

@Kobe Bryant Turns out, COVID kills lots of people. I heard that more frum people have died of COVID in Lakewood in the last month than died of all causes in Lakewood the entire 2019 (!!).

Anybody have any idea how I could further verify if those numbers are accurate or not?

Huh? Only 17 Lakewood people died in 2019? There's gotta be a qualifier that you're missing here.

[Kobe Bryant]

@Kobe Bryant Turns out, COVID kills lots of people. I heard that more frum people have died of COVID in Lakewood in the last month than died of all causes in Lakewood the entire 2019 (!!).

Anybody have any idea how I could further verify if those numbers are accurate or not?

You seem to be intimately familiar. Can you break it down by numbers, age, underlying conditions?

[S209]

Huh? Only 17 Lakewood people died in 2019? There's gotta be a qualifier that you're missing here.

Correct, it sounds ridiculous. I’m trying to figure out what he meant. Perhaps if I could se the data I would realize what he was trying to say.

Perhaps he meant under a certain age?

You seem to be intimately familiar. Can you break it down by numbers, age, underlying conditions?

?

[PlatinumGuy]

https://twitter.com/diseaseecology/status/1325684849416396800?s=21

[ExGingi]

So the entire world is celebrating Pfizer's 90% efficiency of Vaccine candidate. Aren't naturally occurring antibodies more efficient than 90%, yet are being mostly ignored in policy decisions?

#FollowTheMoney #BigPharma

[drosenberg88429]

So the entire world is celebrating Pfizer's 90% efficiency of Vaccine candidate. Aren't naturally occurring antibodies more efficient than 90%, yet are being mostly ignored in policy decisions?

#FollowTheMoney #BigPharma

Unless there's a safe scalable way to generate antibodies (such as a vaccine), we don't want to incentivize infection with the tantalizing prospect of restrictions not applying afterwards.

[S209]

So the entire world is celebrating Pfizer's 90% efficiency of Vaccine candidate. Aren't naturally occurring antibodies more efficient than 90%, yet are being mostly ignored in policy decisions?

#FollowTheMoney #BigPharma

Naturally occurring antibodies kill .65% of patients, not to mention numerous horrific side effects already documented, so I’d prefer to go with the antibodies that may or may not cause transverse myelitis in one in 40,000 cases.

[ExGingi]

Naturally occurring antibodies kill .65% of patients, not to mention numerous horrific side effects already documented, so I’d prefer to go with the antibodies that may or may not cause transverse myelitis in one in 40,000 cases.

The truth that you state doesn't negate the fact that antibodies that have already been shown to exist should be considered in policy decisions.

[aygart]

The truth that you state doesn't negate the fact that antibodies that have already been shown to exist should be considered in policy decisions.

Just because they are not in a final policy doesn't mean they were not considered.

[flyingace]

https://twitter.com/diseaseecology/status/1325684849416396800?s=21

I have a theory that a family member with high antibodies and three negative covid tests within 10 days despite being exposed several times and feeling sick, is due to a severe bout of swine flu around ten years ago. This FM also contracts seasonal flu fairly often. Guess it's not so far-fetched.

[Afrages6]

The truth that you state doesn't negate the fact that antibodies that have already been shown to exist should be considered in policy decisions.

How do you make them part of policy without incentivizing infection?

[S209]

The truth that you state doesn't negate the fact that antibodies that have already been shown to exist should be considered in policy decisions.

The CDC recognizes them as effective regarding quarantine requirements for 3 months, do they not?

[username]

The CDC recognizes them as effective regarding quarantine requirements for 3 months, do they not?

Correct

For Anyone Who Has Been Around a Person with COVID-19
Anyone who has had close contact with someone with COVID-19 should stay home for 14 days after their last exposure to that person.

However, anyone who has had close contact with someone with COVID-19 and who meets the following criteria does NOT need to stay home.

Has COVID-19 illness within the previous 3 months and
Has recovered and
Remains without COVID-19 symptoms (for example, cough, shortness of breath)

[Kobe Bryant]

Correct

Either they are wrong or I have special antibodies..

[Afrages6]

The CDC recognizes them as effective regarding quarantine requirements for 3 months, do they not?

They recognize a positive test
Not antibodies