Author Topic: The science of COVID-19  (Read 49307 times)

Offline PlatinumGuy

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Re: The science of COVID-19
« Reply #380 on: July 17, 2020, 07:31:09 PM »
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Re: The science of COVID-19
« Reply #381 on: July 18, 2020, 11:25:51 PM »
Loss of smell is from brain damage

https://medrxiv.org/cgi/content/short/2020.07.08.20148692v1
Not sure where you are seeing this from that link. Are you confusing the central olfactory system with the brain?
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Offline PlatinumGuy

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Re: The science of COVID-19
« Reply #382 on: July 19, 2020, 01:01:23 AM »
Not sure where you are seeing this from that link. Are you confusing the central olfactory system with the brain?

The central olfactory system is a part of the brain, but regardless:

Quote
Results Hypersignal intensity lesions of the central olfactory system were found in 3 subjects on 3D T2 FLAIR and 2D T2 High Resolution images with a lesion involving the olfactory bulbs and/or the orbitofrontal cortex. These 3 subjects showed a severe and persistent loss of smell on the olfactory test.
« Last Edit: July 19, 2020, 01:14:17 AM by PlatinumGuy »
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״וזה כלל גדול: שישנא אדם כל דבר שקר. וכל מה שיוסיף שנאה לדרכי השקר – יוסיף אהבה לתורה.״ - אורחות צדיקים

Offline Moshe123

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Re: The science of COVID-19
« Reply #384 on: July 21, 2020, 09:58:19 PM »

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״וזה כלל גדול: שישנא אדם כל דבר שקר. וכל מה שיוסיף שנאה לדרכי השקר – יוסיף אהבה לתורה.״ - אורחות צדיקים

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Re: The science of COVID-19
« Reply #386 on: July 26, 2020, 01:50:58 PM »
is it possible to have antibodies if you are blood type O?

Offline Moshe123

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Re: The science of COVID-19
« Reply #387 on: July 26, 2020, 02:21:49 PM »
is it possible to have antibodies if you are blood type O?

Of course!

Offline Danlover111

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Re: The science of COVID-19
« Reply #388 on: July 26, 2020, 02:26:49 PM »
Of course!
i was hearing that blood type O is not getting the virus...

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Re: The science of COVID-19
« Reply #389 on: July 26, 2020, 02:36:25 PM »
i was hearing that blood type O is not getting the virus...

BS. Supposedly a little smaller risk.

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״וזה כלל גדול: שישנא אדם כל דבר שקר. וכל מה שיוסיף שנאה לדרכי השקר – יוסיף אהבה לתורה.״ - אורחות צדיקים

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Re: The science of COVID-19
« Reply #393 on: September 24, 2020, 11:48:14 PM »
This doesn't seem to be written that clearly, at least to an average layman.
I think the gist is that some people are genetically predisposed to have auto-immune responses, the allergy-like attack (cytokine storm) which is responsible for a large percentage of COVID deaths
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Offline Thingywingy

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Re: The science of COVID-19
« Reply #394 on: September 25, 2020, 02:47:43 AM »
https://medical.mit.edu/covid-19-updates/2020/07/when-should-i-be-tested
The diagnostic test, known as a “PCR test,” works by detecting genetic material from SARS-CoV-2, the virus that causes COVID-19, in the nose and upper throat. A study that examined false-negative rates post-exposure, found that during the four days of infection prior to symptom onset, the probability of a false negative on the PCR test went from 100 percent on Day 1 to 67 percent on Day 4. And even on the day individuals began showing symptoms, the false negative rate was still 38 percent, dropping to 20 percent three days after symptom onset. Of course, much depends on the sensitivity of the particular test being used. MIT Medical is using a test that has been shown to have a false-negative rate of less than 5 percent five days post exposure.

I was very surprised by this info that four days after exposure there is still a 67% false-negative rate. Any good sources for how long after exposure a negative test result becomes significantly more reliable? I have seen elsewere that the false-negative rate is 20% on day 8 "post-exposure, or 3 days after symptoms". The language from this study seems to conflate the two variables of days since exposure and onset of symptoms. What is the false negative rate on day 8 if there are no sympoms? Should we expect the rate to be lower?
« Last Edit: September 25, 2020, 03:09:01 AM by Thingywingy »
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Offline biobook

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Re: The science of COVID-19
« Reply #395 on: September 25, 2020, 03:05:35 AM »
This doesn't seem to be written that clearly, at least to an average layman.
Covid-19 is puzzling.  Some people get no symptoms at all, while others get severely ill and may die.  The research just published shows that some of the severe cases were associated with a deficiency in proteins called interferons.

Immunity depends on B cells that produce antibodies, T cells that can destroy infected cells, macrophages that chew up debris, and other cells.  These cells need to communicate with each other to produce an effective immune response, and this communication is based on chemical signaling molecules, called cytokines.  Interferon belongs to this group, and is a chemical that interferes with viral replication.

Researchers found that some people with severe covid-19 had very low interferon levels.  Two different causes were identified: 

Some people produced an antibody which destroyed their own interferon.  It sometimes happens that we make an antibody to recognize a particular infectious agent, and it incidentally recognizes (cross-reacts with) a part of our own body. This can lead to auto-immune disease, where the immune system attacks part of a person's own body. (Multiple sclerosis is an autoimmune disease.)  It's not clear if the covid patients had these rogue antibodies beforehand, or if they developed early in the infection, but at the time they were severely ill, they had very low interferon and so couldn't fight the infection.

The second group of people had a genetic mutation that decreased their ability to produce interferon in the first place, so the end result was the same.

Some implications of these studies:
1. Interferon may be a helpful drug to treat some severely ill patients.
2. A test might be developed to determine if someone has this particular genetic mutation.  For example, relatives of someone who was severely ill might want to know if they are similarly at elevated risk of a severe response to covid.

Offline Thingywingy

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Re: The science of COVID-19
« Reply #396 on: September 25, 2020, 03:16:06 AM »
Covid-19 is puzzling.  Some people get no symptoms at all, while others get severely ill and may die.  The research just published shows that some of the severe cases were associated with a deficiency in proteins called interferons.

Immunity depends on B cells that produce antibodies, T cells that can destroy infected cells, macrophages that chew up debris, and other cells.  These cells need to communicate with each other to produce an effective immune response, and this communication is based on chemical signaling molecules, called cytokines.  Interferon belongs to this group, and is a chemical that interferes with viral replication.

Researchers found that some people with severe covid-19 had very low interferon levels.  Two different causes were identified: 

Some people produced an antibody which destroyed their own interferon.  It sometimes happens that we make an antibody to recognize a particular infectious agent, and it incidentally recognizes (cross-reacts with) a part of our own body. This can lead to auto-immune disease, where the immune system attacks part of a person's own body. (Multiple sclerosis is an autoimmune disease.)  It's not clear if the covid patients had these rogue antibodies beforehand, or if they developed early in the infection, but at the time they were severely ill, they had very low interferon and so couldn't fight the infection.

The second group of people had a genetic mutation that decreased their ability to produce interferon in the first place, so the end result was the same.

Some implications of these studies:
1. Interferon may be a helpful drug to treat some severely ill patients.
2. A test might be developed to determine if someone has this particular genetic mutation.  For example, relatives of someone who was severely ill might want to know if they are similarly at elevated risk of a severe response to covid.
Bloomberg article about Interferon
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Re: The science of COVID-19
« Reply #397 on: September 25, 2020, 10:30:01 AM »
Any foods that are beneficial to Interferon production & regulation?
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