Did you test for antibodies? POLL

[Yard sale]

I don't see where that link refers to sensitivity or specificity rates. I also had symptoms (but negative test at the time), and the Bikur Cholim/Mayo Clinic COR2G test was negative for antibodies. Can't find anything online re sensitivity (i.e. false negative rate), only anecdotal reports of unreasonably high false-negatives in Lakewood and Mayo Clinic's announcement that they are switching to the new test with an EUA.

I believe this is it

[Euclid]

It would make sense that we’d start seeing more negatives now because at first it was only people testing with the assumption that they had the virus. Now people like my brother who don’t think they’ve had it are testing because it’s a requirement for reentering Yeshiva and many shuls.

In other words, this testing cohort is more representative of the general population?

[S209]

In other words, this testing cohort was more representative of the general population?

Perhaps. Though if a significant percentage of people tested early, that would make the numbers higher than what the numbers are showing now. The question is how many tested early and how many are testing now.

[ckey]

I believe this is it

That's probably what they meant, though I don't see that at the link provided.

Also, that is a rate comparing their test to a previous positive or negative PCR test result.  That isn't an indication of the accuracy of this test for numerous reasons. (Edit) Actually, that's just a comparison from PCR to IgM (antibody indicating current infection) which is not the IgG (antibody indicating prior infection) test being discussed at all.

[rcarentals]

Bikur Cholim's test from last Sunday was with the old test, as per my results sheet.

+1 - mine shows as "COR2G".
I got a negative, but pretty confident it's accurate.

[PlatinumGuy]

I don't see where that link refers to sensitivity or specificity rates. I also had symptoms (but negative test at the time), and the Bikur Cholim/Mayo Clinic COR2G test was negative for antibodies. Can't find anything online re sensitivity (i.e. false negative rate), only anecdotal reports of unreasonably high false-negatives in Lakewood and Mayo Clinic's announcement that they are switching to the new test with an EUA.

http://www.epitopediagnostics.com/covid-19-elisa

https://www.sciencedirect.com/science/article/pii/S1386653220301360?via%3Dihub

We found a sensitivity of 86.4 %, 100 %, 86.4 %, and 77.3 % and a specificity of 96,2 %, 88,7 %, 100 %, and 100 % for the Euroimmun assay, the EDI assay, the Mikrogen assay, and the Viramed assay, respectively.

[bingit]

Me & wife took Bikur Cholim test in Lakewood, I got my results last week & by wife it says they did not get results yet, did anyone else that did Bikkur cholim test not get results?

[bingit]

I was positive (was sick for 10 days after Purim) my number was 2.50 does anyone know what that means with the Mayo test?

[Yard sale]

Relatively high level of antibodies

[S209]

Relatively high level of antibodies

Honestly I’m confused by the different numbers. What do the numbers on the various tests mean? Do you know?

[Yard sale]

Honestly I’m confused by the different numbers. What do the numbers on the various tests mean? Do you know?

Not really. All I know is that ELISA (the Mayo test method used) measures the standard deviation of the sample and expresses it as a number (sample/control) where above 1.2 is considered conclusive. As you go higher there is a higher presence of antibodies detected. 2.5 would be two and a half standard deviations. I’m not familiar with the upper range. I know quite a few positives were in the upper ones.I’ll leave the rest to those who are more familiar.

[etech0]

Not really. All I know is that ELISA (the Mayo test method used) measures the standard deviation of the sample and expresses it as a number (sample/control) where above 1.2 is considered conclusive. As you go higher there is a higher presence of antibodies detected. 2.5 would be two and a half standard deviations. I’m not familiar with the upper range. I know quite a few positives were in the upper ones.I’ll leave the rest to those who are more familiar.

I have a relative who got >4.4

[JuryDuty]

4 people in my family tested with bikur cholim - mayo.

1. Symptoms: loss of smell. Results: "pending"
2. No symptoms, inconclusive.
3. No symptoms, negative.
4. No symptoms, positive (1.86).

[JuryDuty]

Per their website Mayo is using a test without even an EUA and claimed specifity of around 85%

https://www.mayocliniclabs.com/test-catalog/Performance/609035

http://www.epitopediagnostics.com/covid-19-elisa

https://www.sciencedirect.com/science/article/pii/S1386653220301360?via%3Dihub

Dan posted these pages demonstrating that mayo clinic is only 88 percent accurate. Anyone can help interpret these pages?@biobook?

[ari3]

Me & wife took Bikur Cholim test in Lakewood, I got my results last week & by wife it says they did not get results yet, did anyone else that did Bikkur cholim test not get results?

same here. emailed them twice and was told to keep checking periodicaly

[biobook]

Dan posted these pages demonstrating that mayo clinic is only 88 percent accurate. Anyone can help interpret these pages?@biobook?

I really don't know anything about this yet, but I'm willing to try to figure it out.  I'm not sure what you're asking, so I'll answer one question that I see above, and if you have others, let me know and I'll try to look into that tomorrow.  But if someone really understands it, please chime in.

What does the number on the positive antibody test mean?

From what I can understand, it should be considered meaningless. 
 
The EDI IgG says "This kit is intended for the qualitative detection of human anti-COVID-19 antibody..." and the Mayo test says "This test provides qualitative detection of serum IgG-class antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)" https://www.mayocliniclabs.com/test-catalog/Overview/609035

Qualitative, not quantitative.  Although the test spits out a number, it should only be understood as a yes/no answer.  Like a pregnancy test, where the line turns blue if you're pregnant. The intensity of the blue color may differ in different cases, but darker blue doesn't mean that you're further along in pregnancy, or that you have twins instead of a singleton.  It just means Yes!  Mazel tov!

So you're wondering (as am I) why there's a number in the first place?  I think that the test really is meant to measure the quantitative amount of antibody present, but for whatever reason, they don't think it's giving a reliable result.  It may have to do with the test procedure (maybe the number changes if it sits around a few minutes longer before it's read) or it might have to do with the antibodies in the blood (perhaps the amount naturally varies over the course of the day).  (I'm making these up.)  I'm sure that they're working on developing a reliable quantitative test, but for now, they seem to be saying to just consider the result positive, and ignore the number.  Or some tests may not even give you a number, and just say Positive. 

Here's a worthwhile discussion of the value of the antibody tests at this time.
https://www.npr.org/sections/health-shots/2020/05/21/857961304/getting-an-antibody-test-for-the-coronavirus-heres-what-it-wont-tell-you

[JuryDuty]

I was asking if you could look at the 3 links Dan posted and interpret them for the laymen. He copied those links to demonstrate that mayo clinic is only 88% accurate.

[etech0]

I really don't know anything about this yet, but I'm willing to try to figure it out.  I'm not sure what you're asking, so I'll answer one question that I see above, and if you have others, let me know and I'll try to look into that tomorrow.  But if someone really understands it, please chime in.

What does the number on the positive antibody test mean?

From what I can understand, it should be considered meaningless. 
 
The EDI IgG says "This kit is intended for the qualitative detection of human anti-COVID-19 antibody..." and the Mayo test says "This test provides qualitative detection of serum IgG-class antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)" https://www.mayocliniclabs.com/test-catalog/Overview/609035

Qualitative, not quantitative.  Although the test spits out a number, it should only be understood as a yes/no answer.  Like a pregnancy test, where the line turns blue if you're pregnant. The intensity of the blue color may differ in different cases, but darker blue doesn't mean that you're further along in pregnancy, or that you have twins instead of a singleton.  It just means Yes!  Mazel tov!

So you're wondering (as am I) why there's a number in the first place?  I think that the test really is meant to measure the quantitative amount of antibody present, but for whatever reason, they don't think it's giving a reliable result.  It may have to do with the test procedure (maybe the number changes if it sits around a few minutes longer before it's read) or it might have to do with the antibodies in the blood (perhaps the amount naturally varies over the course of the day).  (I'm making these up.)  I'm sure that they're working on developing a reliable quantitative test, but for now, they seem to be saying to just consider the result positive, and ignore the number.  Or some tests may not even give you a number, and just say Positive. 

Here's a worthwhile discussion of the value of the antibody tests at this time.
https://www.npr.org/sections/health-shots/2020/05/21/857961304/getting-an-antibody-test-for-the-coronavirus-heres-what-it-wont-tell-you

Interesting, thanks!

What are your thoughts re: a situation like this:

For those who got a negative result, did you look at the paperwork to check if you have some antibodies, but not 'enough' to be considered positive?

[Dan]

I was asking if you could look at the 3 links Dan posted and interpret them for the laymen. He copied those links to demonstrate that mayo clinic is only 88% accurate.

Not quite.
https://www.dansdeals.com/more/dans-commentary/news-roundup/covid-19-news-roundup-5-25-20-super-spreaders-second-wave-immunity-passports-el-al-turkey-worldwide-restrictions-roundup-amare-stoudemire/

I said "88% specificity for COVID-19."

[AsherO]

Not quite.
https://www.dansdeals.com/more/dans-commentary/news-roundup/covid-19-news-roundup-5-25-20-super-spreaders-second-wave-immunity-passports-el-al-turkey-worldwide-restrictions-roundup-amare-stoudemire/

I said "88% specificity for COVID-19."

Which means that in 12% of the cases the person might have antibodies to something else? A different Coronavirus?