Author Topic: Dropping Antibody Levels  (Read 29168 times)

Online Shmulie

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Re: Dropping Antibody Levels
« Reply #400 on: April 16, 2021, 11:56:58 AM »
How long does it take to get results for the LabCorp test

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Re: Dropping Antibody Levels
« Reply #401 on: April 16, 2021, 12:11:01 PM »
How long does it take to get results for the LabCorp test
For the quant test? A couple days.
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Re: Dropping Antibody Levels
« Reply #402 on: April 19, 2021, 11:16:15 AM »
For the quant test? A couple days.

I got the labcorp test done on Friday afternoon and just got the results
apparently I have >250.00, no idea if that's high or not but I think >80 is considered positive

For reference I tested positive for Covid about a week after purim 2020, so this is after a year

« Last Edit: April 19, 2021, 11:21:02 AM by Shmulie »

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Re: Dropping Antibody Levels
« Reply #403 on: April 19, 2021, 11:19:38 AM »
I got the labcorp test done on Friday afternoon and just got the results
apparently I have >250.00, no idea if that's high or not but I think >80 is considered positive
Greater than 0.8 is positive.
Greater than 250 is off the charts high.

I had 192.6 in January, some 11 months after I had COVID. I'm pretty sure I'd test at greater than 250 now after bring vaccinated.
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Re: Dropping Antibody Levels
« Reply #404 on: April 19, 2021, 11:21:58 AM »
Greater than 0.8 is positive.
Greater than 250 is off the charts high.

I had 192.6 in January, some 11 months after I had COVID. I'm pretty sure I'd test at greater than 250 now after bring vaccinated.

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Re: Dropping Antibody Levels
« Reply #405 on: June 23, 2021, 09:08:47 AM »
A relative got Covid in Mar/Apr 2020. Antibodies test in Mar 21 came back at 279. Antibodies test 3.5 months later came back at 376. AFAIK, it's the same test. Has anyone seen this happen before? Any links that would explain how this could happen?
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Re: Dropping Antibody Levels
« Reply #406 on: June 23, 2021, 10:08:15 AM »
A relative got Covid in Mar/Apr 2020. Antibodies test in Mar 21 came back at 279. Antibodies test 3.5 months later came back at 376. AFAIK, it's the same test. Has anyone seen this happen before? Any links that would explain how this could happen?

Exposure?

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Re: Dropping Antibody Levels
« Reply #407 on: June 23, 2021, 10:14:46 AM »
Exposure?

It's a possible theory. I'm looking for any data to support it. Or any data at all, really.
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Re: Dropping Antibody Levels
« Reply #408 on: June 23, 2021, 10:39:18 AM »
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Re: Dropping Antibody Levels
« Reply #409 on: June 23, 2021, 11:56:36 AM »
Solid theory.

Something @ExGingi has been talking about for a long time now. I'd be very interested to see if anyone is collecting data on this. May bring exposure parties back en vogue (a la chickenpox parties).
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Re: Dropping Antibody Levels
« Reply #410 on: June 23, 2021, 12:02:31 PM »
Something @ExGingi has been talking about for a long time now. I'd be very interested to see if anyone is collecting data on this. May bring exposure parties back en vogue (a la chickenpox parties).
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Offline biobook

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Re: Dropping Antibody Levels
« Reply #411 on: June 23, 2021, 12:33:14 PM »
@biobook
The first thing that comes to mind is that a change in antibody tests from 279 to 376 is not necessarily a significant increase.  What you'd want to know is how much variability is there in antibody levels in general.  For example, if antibodies tend to be higher in the morning than in the afternoon, then you could find a seeming "increase" in antibodies by measuring in the afternoon the first time and then in the morning on the second test, 3 months later.  Doesn't mean antibodies are getting higher, just that you've looked at a different point in the cycling levels. 

I don't know how antibodies normally cycle, but I do remember posting something along these lines a while back, in response to something.  Maybe @TimT can find it?  I vaguely remember a graph showing several individuals and measurements of their antibody levels at different times, and it was not a straight line. 

The second thought that comes to mind is that it does take a while for maximal antibody response to develop after an infection, so if the first test was soon after getting sick, then the second test might simply be showing the natural continuation of that antibody response.  Again, this is a vague memory, but I think I had posted something about this, that it took some time to develop.  Can't remember if it was a few weeks, or a few months.  Maybe @TimT can find that too?

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Re: Dropping Antibody Levels
« Reply #412 on: June 23, 2021, 12:33:37 PM »
Something @ExGingi has been talking about for a long time now. I'd be very interested to see if anyone is collecting data on this. May bring exposure parties back en vogue (a la chickenpox parties).

Can exposure parties for people with antibodies lead to new mutations? There are known/extant mutations that evade antibodies, fortunately they haven't been significantly more transmissible. A variant that's as transmissible as Delta combined with mutations that evade antibodies would be catastrophic, even in vaccinated societies.

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Re: Dropping Antibody Levels
« Reply #413 on: June 23, 2021, 12:39:07 PM »
I did not have (enough to be considered positive) antibodies at 2 months, but did at 4. Anecdotal, yes.
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Re: Dropping Antibody Levels
« Reply #414 on: June 23, 2021, 12:44:02 PM »


The first point is interesting. I have to find out more about the timing. The second point is actually why I'm so curious. In this particular case, the first test was about one year post infection, so well after the time frame I thought it took to build up a full antibody response, and the second test was 15 months post infection. While I wouldn't be surprised if the levels stayed the same, but I'd expect any change to show a decrease, not an increase, that long post infection.
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Re: Dropping Antibody Levels
« Reply #415 on: June 23, 2021, 12:48:37 PM »
Can exposure parties for people with antibodies lead to new mutations? There are known/extant mutations that evade antibodies, fortunately they haven't been significantly more transmissible. A variant that's as transmissible as Delta combined with mutations that evade antibodies would be catastrophic, even in vaccinated societies.

IINM, variants evading antibodies is far from an exact science. I believe the only data we may have is that some variants are more likely to evade antibodies from other strains, but I haven't seen any numbers to show how common it is. There are probably a number of risks for exposure parties, but it may be an alternative for people with antibodies  who are wary of the vaccines, if the risks are found to be low enough.
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Re: Dropping Antibody Levels
« Reply #416 on: June 23, 2021, 01:07:57 PM »
The first thing that comes to mind is that a change in antibody tests from 279 to 376 is not necessarily a significant increase.  What you'd want to know is how much variability is there in antibody levels in general.  For example, if antibodies tend to be higher in the morning than in the afternoon, then you could find a seeming "increase" in antibodies by measuring in the afternoon the first time and then in the morning on the second test, 3 months later.  Doesn't mean antibodies are getting higher, just that you've looked at a different point in the cycling levels. 

I don't know how antibodies normally cycle, but I do remember posting something along these lines a while back, in response to something.  Maybe @TimT can find it?  I vaguely remember a graph showing several individuals and measurements of their antibody levels at different times, and it was not a straight line. 

The second thought that comes to mind is that it does take a while for maximal antibody response to develop after an infection, so if the first test was soon after getting sick, then the second test might simply be showing the natural continuation of that antibody response.  Again, this is a vague memory, but I think I had posted something about this, that it took some time to develop.  Can't remember if it was a few weeks, or a few months.  Maybe @TimT can find that too?
Referring to this one ?
Here's a partial answer. Quebec researchers measured antibody levels in recovered covid patient who donated convalescent plasma repeatedly. Each line on the graph is another person.  Although antibodies decreased in general over this time period, you can see it fluctuates, and sometimes one measurement is actually higher than the previous one in that person.

https://ashpublications.org/blood/article/doi/10.1182/blood.2020008367/463996/Waning-of-SARS-CoV-2-RBD-antibodies-in
The authors ask whether the repeated donations might actually be responsible for the decline in antibodies. When @Dan suggested this a month ago, I answered that I thought it unlikely based on theoretical issues. The authors apparently did consider it possible, but also concluded that it's unlikely, based on their results here. Their reasoning was that if donating antibodies depleted the supply, then antibody levels should drop more rapidly in those who donated more times, but there was no such correlation.

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Re: Dropping Antibody Levels
« Reply #417 on: June 23, 2021, 01:17:31 PM »
IINM, variants evading antibodies is far from an exact science. I believe the only data we may have is that some variants are more likely to evade antibodies from other strains, but I haven't seen any numbers to show how common it is. There are probably a number of risks for exposure parties, but it may be an alternative for people with antibodies  who are wary of the vaccines, if the risks are found to be low enough.

Perhaps not an exact science, but certainly a scientific fact.

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Re: Dropping Antibody Levels
« Reply #418 on: June 23, 2021, 01:19:18 PM »
Perhaps not an exact science, but certainly a scientific fact.

Definitely a fact that it happens. I'd like to see data that shows how likely it is to happen.
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Offline AsherO

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Re: Dropping Antibody Levels
« Reply #419 on: June 23, 2021, 01:23:52 PM »
Definitely a fact that it happens. I'd like to see data that shows how likely it is to happen.

Not sure how that can be ascertained. Do you mean comparing patient outcomes with/without mutations when all other conditions are equal?

Hard to do, because when these mutations are in the present strain, they present in everyone infected in that particular population. Also, you'd have to sequence all test subjects in the population, which is costly.