Realistic vaccine date- end of 2021?

[grodnoking]

https://www.cnn.com/2021/01/29/health/johnson-coronavirus-vaccine-results/index.html

Ouch.

Any data on if it reduces severity of cases after the vaccine?

[PlatinumGuy]

Any data on if it reduces severity of cases after the vaccine?

Yes around 85% effective against severe disease IINM.
The 60% figures don’t do it justice

[Moshe123]

Why is there no mention from J&J on the efficacy in regards to preventing infection?

[AsherO]

Why is there no mention from J&J on the efficacy in regards to preventing infection?

What do you think the 66% (global) and 72% (US) numbers are?

[Moshe123]

What do you think the 66% (global) and 72% (US) numbers are?

Moderate to severe illness. What about the tier below that?

[AsherO]

Moderate to severe illness. What about the tier below that?

See the chart in this article, I think the clinical trials must have been designed differently with different endpoints being studied.

https://www.theverge.com/2021/1/30/22257557/antivirus-johnson-and-johnson-vaccine-results

[PlatinumGuy]

Moderate to severe illness. What about the tier below that?

Moderate is probably any symptom, and without repetitively testing the entire sample cohort, there is no way to know about asymptomatic infection.

They didn't test for it because they didn't want to have the number...

[yzj]

https://baltimore.cbslocal.com/2020/07/29/johns-hopkins-press-conference-coronavirus-pandemic-latest/

Can any places other than China keep up social distancing protocols for another 15 months? Or are we going to continue to see increasing flare-up and waves as countries throw in the towel?

https://www.wsj.com/articles/covid-19-vaccine-setbacks-damp-europes-prospects-for-normal-summer-11611597792?mod=searchresults_pos2&page=1&mod=article_inline


“The EU, which centralizes vaccine procurement for its members, has ordered 2.3 billion doses from six manufacturers and set a target for the region’s governments to immunize 70% of adults in the bloc by the summer, a goal that seems increasingly out of reach.

This means there is little hope of an end to lockdowns and other constraints on public life soon,”

[Traveler718]

Antibody can be produced in two cases: when you are infected with the virus, and when you get the vaccine. Antibody looks the same in both cases.  The antibody test just picks up antibody, and the test doesn't "know" whether the antibody had been made in response to the virus or to the vaccine. A positive antibody test doesn't "prove" that you are immune, that is, we don't yet know how much antibody you need to be considered immune.  But whatever that number is, it shouldn't matter whether you got there as a result of getting covid, or as a result of getting the vaccine.   

A doctor in Far Rockaway whose virus updates I receive sent out the following yesterday, which seems to say that the antibodies produced by the vaccine are NOT necessarily the same as those produced in response to infection. Similarly, Rabbi Dr. Glatt said in one of his recent Motzei Shabbos programs that he was surprised that several of his medical colleagues tested themselves for antibodies after getting vaccinated and were disappointed that their tests came back negative. He explained that the antibodies tested for by current antibody tests are not necessarily the same as those produced by the vaccine, so he discouraged those who've been vaccinated from doing so. Any additional insights on this topic @biobook or anyone else?


At this time, it is NOT recommended that vaccinated people test for antibodies.
 
Current data indicates that most vaccinated people will develop a significant degree of immunity by two weeks after their second dose.
 
However, it is possible that vaccinated people will produce antibodies that differ slightly from those produced by actual infection and therefore will not be detected by current lab tests.
 
New antibody tests will hopefully be available in the near future that will test for the specific type of antibodies produced after vaccination.

[PlatinumGuy]

Yes, vaccines produce a narrow subset of infection antibodies, and some assays won't detect those.

[incendia]

A doctor in Far Rockaway whose virus updates I receive sent out the following yesterday, which seems to say that the antibodies produced by the vaccine are NOT necessarily the same as those produced in response to infection. Similarly, Rabbi Dr. Glatt said in one of his recent Motzei Shabbos programs that he was surprised that several of his medical colleagues tested themselves for antibodies after getting vaccinated and were disappointed that their tests came back negative. He explained that the antibodies tested for by current antibody tests are not necessarily the same as those produced by the vaccine, so he discouraged those who've been vaccinated from doing so. Any additional insights on this topic @biobook or anyone else?


At this time, it is NOT recommended that vaccinated people test for antibodies.
 
Current data indicates that most vaccinated people will develop a significant degree of immunity by two weeks after their second dose.
 
However, it is possible that vaccinated people will produce antibodies that differ slightly from those produced by actual infection and therefore will not be detected by current lab tests.
 
New antibody tests will hopefully be available in the near future that will test for the specific type of antibodies produced after vaccination.

The vaccines only replicates one part (spike protein) of the virus so your body can only make antibodies for that part but its enough to give you protection from getting sick.

A natural infection will produce antibodies for several different parts of the virus. They must be testing for one or more of the antibodies not used in the vaccine.

[how]

A doctor in Far Rockaway whose virus updates I receive sent out the following yesterday, which seems to say that the antibodies produced by the vaccine are NOT necessarily the same as those produced in response to infection. Similarly, Rabbi Dr. Glatt said in one of his recent Motzei Shabbos programs that he was surprised that several of his medical colleagues tested themselves for antibodies after getting vaccinated and were disappointed that their tests came back negative. He explained that the antibodies tested for by current antibody tests are not necessarily the same as those produced by the vaccine, so he discouraged those who've been vaccinated from doing so. Any additional insights on this topic @biobook or anyone else?


At this time, it is NOT recommended that vaccinated people test for antibodies.
 
Current data indicates that most vaccinated people will develop a significant degree of immunity by two weeks after their second dose.
 
However, it is possible that vaccinated people will produce antibodies that differ slightly from those produced by actual infection and therefore will not be detected by current lab tests.
 
New antibody tests will hopefully be available in the near future that will test for the specific type of antibodies produced after vaccination.

But if you did test for antibodies after taking the vaccine and you did get a positive result - does that prove that you now have antibodies?

[PlatinumGuy]

But if you did test for antibodies after taking the vaccine and you did get a positive result - does that prove that you now have antibodies?

They may not be fully effective yet.

[PlatinumGuy]

Maybe instead of shots per day, it's also worth thinking about TIME: how long it would take to vaccinate the country. Here's a little conversion table for that, assuming you want to vaccinate 80% of the US population including children. pic.twitter.com/OkeDlDknMq

— Nate Silver (@NateSilver538) January 30, 2021

There is light at the end of the tunnel

[Dan]

A doctor in Far Rockaway whose virus updates I receive sent out the following yesterday, which seems to say that the antibodies produced by the vaccine are NOT necessarily the same as those produced in response to infection. Similarly, Rabbi Dr. Glatt said in one of his recent Motzei Shabbos programs that he was surprised that several of his medical colleagues tested themselves for antibodies after getting vaccinated and were disappointed that their tests came back negative. He explained that the antibodies tested for by current antibody tests are not necessarily the same as those produced by the vaccine, so he discouraged those who've been vaccinated from doing so. Any additional insights on this topic @biobook or anyone else?


At this time, it is NOT recommended that vaccinated people test for antibodies.
 
Current data indicates that most vaccinated people will develop a significant degree of immunity by two weeks after their second dose.
 
However, it is possible that vaccinated people will produce antibodies that differ slightly from those produced by actual infection and therefore will not be detected by current lab tests.
 
New antibody tests will hopefully be available in the near future that will test for the specific type of antibodies produced after vaccination.

Fake news.
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