Realistic vaccine date- end of 2021?

[PlatinumGuy]

Biden announcing his administration has signed contracts for an additional 200 million vaccines by Pfizer and Moderna by July - meaning all Americans 16+ will be vaccinated.  Also speeding up earlier order for 100 million to May.  

Thank goodness we won the election!

— Amy Siskind 🏳️‍🌈 (@Amy_Siskind) February 11, 2021

(I didn�t fact-check)

[PlatinumGuy]

We have just uploaded a pre-print to MedRxiv sharing our data on the potential for sera from recipients of currently administered mRNA vaccines to neutralize 10 different circulating strains of #SARSCoV2.  Before it posts online, I'd like to put them into context.  A thread:
1/12

— Balazs Lab (@BalazsLab) February 14, 2021

Some data on vaccines vs variants

[Jerseysteve]

https://www.msn.com/en-us/news/us/how-to-beat-the-pandemic-by-summer/ar-BB1dEcc7?ocid=uxbndlbing

[Lurker]

https://www.msn.com/en-us/news/us/how-to-beat-the-pandemic-by-summer/ar-BB1dEcc7?ocid=uxbndlbing

Big fan of point #2, especially if we focus on the younger adults. The example given about headlights on cars was interesting, and I'd take it one step further. I'd rather have one headlight on every car on the road (or even half the cars on the road), than working headlights on parked cars.

The biggest mistake in this article, IMO, is the first paragraph:

After nearly a year of social isolation and sacrifice in the long war on COVID-19, the end stage of the pandemic is finally in sight. Millions of Americans are being vaccinated each week, and the number of coronavirus-related hospitalizations in the United States has plunged by more than 40 percent in the past month.

Correlating the numbers going down from the second wave with the vaccine rollout may ultimately cause serious harm when the third wave hits.

[PlatinumGuy]

Per a source, the power outages hit a county facility storing vaccines. Officials now attempting to distribute approx 8,000 vaccines so they don't go to waste. Notices sent to Rice University/Jail. Confirmed @HCSOTexas received about 3k vaccines, must be used today.

— St. John Barned-Smith ⚔️ (@stjbs) February 15, 2021

[PlatinumGuy]

So phenomenal news from today's testimony from J&J executives

They will ship 20M of these single-shot vaccines before end of March

Every calculation I've done assumed no J&J vax until April

Ah you say -- but don't I want Moderna/Pfizer? Aren't they better??

No

Thread

— Ashish K. Jha, MD, MPH (@ashishkjha) February 23, 2021

[AsherO]

So phenomenal news from today's testimony from J&J executives

They will ship 20M of these single-shot vaccines before end of March

Every calculation I've done assumed no J&J vax until April

Ah you say -- but don't I want Moderna/Pfizer? Aren't they better??

No

Thread

— Ashish K. Jha, MD, MPH (@ashishkjha) February 23, 2021

J&J doesn�t have data from US clinical trials like AZN has? Idk why I conflated the two and thought that�s what was holding up JNJ�s data from getting sent to the FDA

[Ergel]

Did J&J test on kids?
Does Israel have outstanding order with J&J?

[AsherO]

Did J&J test on kids?
Does Israel have outstanding order with J&J?

I think the answer to both questions is no:

https://www.reuters.com/article/health-coronavirus-j-j-idUSKBN27F2MP

[Moshe123]

https://www.wsj.com/articles/moderna-says-covid-19-vaccine-for-south-africa-strain-is-ready-for-human-testing-11614201000?redirect=amp#click=https://t.co/QMY1X0LDJs

[AsherO]

https://www.wsj.com/articles/moderna-says-covid-19-vaccine-for-south-africa-strain-is-ready-for-human-testing-11614201000?redirect=amp#click=https://t.co/QMY1X0LDJs

Very nice. It isn�t possible to make a hybrid that includes U.K. , SA, Brazil, LA, etc. variants all all in one?

[yzj]

Reminds me of Whack-A-Mole

[PlatinumGuy]

Very nice. It isn�t possible to make a hybrid that includes U.K. , SA, Brazil, LA, etc. variants all all in one?

As long as you have to pay Moderna individually...

[AsherO]

As long as you have to pay Moderna individually...

If they had an omni-variant vaccine then they�d likely be able to sell as much as they produce for a long while. I wonder if it�s a monetary thing like you�re suggesting, or maybe there are scientific/technical development/production issues involved in bringing an omni-variant vaccine to market.

[incendia]

The flu vaccine is 3-4 different vaccines at once and MMR is 3 in 1, so its definitely possible to multiples vaccines in one shot. I don't know if it possible or feasible to do a MRNA vaccine that way.