"I would implore everybody who's celebrating today to remember, it's good to be a humble winner.
"Remember when I was here four years ago, remember how bad that felt? Remember that half the country right now still feels that way," Chappelle said, referring to his first hosting gig on the show in 2016.
He brought up President Donald Trump's coronavirus diagnosis, joking that the President had great coverage in his personal health care plan, which provided him with a ride to the hospital in a helicopter, a team of doctors and experimental medications.
Chappelle said Trump's special treatment while he was ill was like taking a bag of burgers to a homeless shelter, eating them in front of the homeless and saying, "don't let hunger dictate your life," mimicking the President's infamous tweet after his recovery, when he told Americans not to fear Covid or let it dominate their lives.
But, he said, Herman Cain died of coronavirus and former New Jersey Gov. Chris Christie was in intensive care with it.
"Where was his secret serum?" he asked of Cain's treatment.
"That's your leader. Think about that, for four years, that's your leader. What kind of man does that? What kind of man makes sure he's OK, while his friends are fighting for their lives and die?
"A White man. And I don't mean to put this on the Whites, but I've been Black for a long time, I notice the pattern."