Poll

1 Or 2 Vaccine Doses For People Who Had COVID?

Get 1 dose and wait and see what updated guidance says
10 (52.6%)
Get 2 doses and be done with it
9 (47.4%)

Total Members Voted: 19

Author Topic: 1 Or 2 Vaccine Doses For People Who Had COVID?  (Read 3896 times)

Offline RobsPoints

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Re: 1 Or 2 Vaccine Doses For People Who Had COVID?
« Reply #30 on: March 15, 2021, 05:22:00 PM »
So if the best marker we have is the antibodies, why not use them as some sort of indication?

How in the world do they determine that the vaccines are effective in clinical trials (I get the huge trial in Israel as being somewhat indicative, but why not combine it with antibody testing to get a better indication?)

As I noted, Israeli green pass is issued 10 days after 2nd dose, and is valid for six months. Recovery within Israel gives a תעודת מחלים regardless of when recovery occurred and is valid until 6/30/2021.
Antibodies are only one aspect of immune response. Antibodies can disappear after a few months, but memory T Cells can provide ongoing immunity. There's no way to measure T cell response or know how long it lasts without further study.   

Clinical trials give half the people the vaccine and half the people a placebo.  Then they check in a few months later. If there are 50 people that get sick from the disease in the placebo group, and only 5 people in the group that got the vaccine, they say the vaccine prevented 45 illnesses that we would have otherwise expected to see in a group of that size that didn't get a vaccine.  So they say the vaccine is 45/50 or 90% effective at preventing disease.

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Re: 1 Or 2 Vaccine Doses For People Who Had COVID?
« Reply #31 on: March 15, 2021, 05:40:26 PM »
As I noted, Israeli green pass is issued 10 days after 2nd dose, and is valid for six months.
For now
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Offline ExGingi

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Re: 1 Or 2 Vaccine Doses For People Who Had COVID?
« Reply #32 on: March 15, 2021, 08:46:37 PM »
Antibodies are only one aspect of immune response. Antibodies can disappear after a few months, but memory T Cells can provide ongoing immunity. There's no way to measure T cell response or know how long it lasts without further study.   

Clinical trials give half the people the vaccine and half the people a placebo.  Then they check in a few months later. If there are 50 people that get sick from the disease in the placebo group, and only 5 people in the group that got the vaccine, they say the vaccine prevented 45 illnesses that we would have otherwise expected to see in a group of that size that didn't get a vaccine.  So they say the vaccine is 45/50 or 90% effective at preventing disease.

But did they ever do similar studies with people who recovered?
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Offline S209

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Re: 1 Or 2 Vaccine Doses For People Who Had COVID?
« Reply #33 on: March 15, 2021, 10:04:22 PM »
But did they ever do similar studies with people who recovered?
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Offline iwlw2

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Re: 1 Or 2 Vaccine Doses For People Who Had COVID?
« Reply #34 on: March 18, 2021, 12:06:44 PM »
Bumping this question as it is now BH relevant to me as well.
Got my first (Moderna) shot yesterday. Arm definitely sore, and I feel some fatigue and general blaah, but that may be more related to this time of year.... ;)
I had Covid a year ago, and eventually tested positive for high levels of antibodies and donated plasma, am very curious about whether a second shot is all that beneficial or necessary for me. Any updated info on this from anyone?

Offline ExGingi

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Re: 1 Or 2 Vaccine Doses For People Who Had COVID?
« Reply #35 on: March 18, 2021, 12:17:33 PM »
Bumping this question as it is now BH relevant to me as well.
Got my first (Moderna) shot yesterday. Arm definitely sore, and I feel some fatigue and general blaah, but that may be more related to this time of year.... ;)
I had Covid a year ago, and eventually tested positive for high levels of antibodies and donated plasma, am very curious about whether a second shot is all that beneficial or necessary for me. Any updated info on this from anyone?

Did you check your antibodies shortly prior to getting vaccinated?

I did and they were low, which is why I took the first dose. 6 days later I tested my antibodies and they were very high. I am postponing the 2nd dose until a time when I see a benefit to taking it (either having it recognized for a green pass in Israel, or if I see that my antibodies are low again).
I've been waiting over 5 years with bated breath for someone to say that!
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Offline AsherO

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Re: 1 Or 2 Vaccine Doses For People Who Had COVID?
« Reply #36 on: March 18, 2021, 12:24:48 PM »
Did you check your antibodies shortly prior to getting vaccinated?

I did and they were low, which is why I took the first dose. 6 days later I tested my antibodies and they were very high. I am postponing the 2nd dose until a time when I see a benefit to taking it (either having it recognized for a green pass in Israel, or if I see that my antibodies are low again).

Hopefully you realize that waiting to take a second shot could (potentially, it's unknown now) lead to your second shot being less effective. The medical establishment  does not yet have a consensus on this issue, so recommendations vary.

Offline iwlw2

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Re: 1 Or 2 Vaccine Doses For People Who Had COVID?
« Reply #37 on: March 18, 2021, 12:43:53 PM »
Did you check your antibodies shortly prior to getting vaccinated?

I did and they were low, which is why I took the first dose. 6 days later I tested my antibodies and they were very high. I am postponing the 2nd dose until a time when I see a benefit to taking it (either having it recognized for a green pass in Israel, or if I see that my antibodies are low again).
I did not check, in fact havenot checked since I initially got the antibody test last April, so no idea about those. Just no reason for me to take a second shot if a)it wont help me that much anyhow, b) could delay someone else getting their first (or second who never had covid).
(Incidentally, I feel quite lousy now, hopeful it wont last for too long....)

Offline Dan

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Re: 1 Or 2 Vaccine Doses For People Who Had COVID?
« Reply #38 on: March 18, 2021, 12:48:21 PM »
(Incidentally, I feel quite lousy now, hopeful it wont last for too long....)
Seems common among people who had COVID. Lasted a couple days for me.
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Offline Dan

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Re: 1 Or 2 Vaccine Doses For People Who Had COVID?
« Reply #39 on: March 18, 2021, 12:48:55 PM »
Did you check your antibodies shortly prior to getting vaccinated?

I did and they were low, which is why I took the first dose. 6 days later I tested my antibodies and they were very high. I am postponing the 2nd dose until a time when I see a benefit to taking it (either having it recognized for a green pass in Israel, or if I see that my antibodies are low again).
When you're bored, take the Roche quant at Labcorp.
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Offline Dan

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Re: 1 Or 2 Vaccine Doses For People Who Had COVID?
« Reply #40 on: March 18, 2021, 12:51:20 PM »
Hopefully you realize that waiting to take a second shot could (potentially, it's unknown now) lead to your second shot being less effective. The medical establishment  does not yet have a consensus on this issue, so recommendations vary.
Right, this is why I'll probably get the 2nd shot. For example Iceland has strict requirements on how long you can wait for the Pfizer or AZN 2nd shot and still enter without quarantine.
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Re: 1 Or 2 Vaccine Doses For People Who Had COVID?
« Reply #41 on: March 18, 2021, 01:49:47 PM »
Right, this is why I'll probably get the 2nd shot. For example Iceland has strict requirements on how long you can wait for the Pfizer or AZN 2nd shot and still enter without quarantine.

Exactly. Taking the 2nd shot is all about the actual benefit in avoiding restrictions (as was the first shot, which performed exactly as expected). For me it's all about removing restrictions in Israel. I might even choose to get 2 shots in Israel, if that's what is likely to get me a green pass faster than any other conceivable option.

As to effectiveness. I am glad the medical professionals are willing to say we don't know, and I'll leave it at that.
I've been waiting over 5 years with bated breath for someone to say that!
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Re: 1 Or 2 Vaccine Doses For People Who Had COVID?
« Reply #42 on: March 18, 2021, 02:16:31 PM »
As to effectiveness. I am glad the medical professionals are willing to say we don't know, and I'll leave it at that.

By the time they know it might be too late for maximal/optimal effectiveness. I don't think it's a big deal, but some experts do.

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