Will you get the booster shot?

[CountValentine]

When do I get my second booster?

[AsherO]

There actually was a study in the Netherlands that seemed to imply something like that about the boosters. Not vouching for it as I have no info about their bias or lack thereof.


Israel seemed to stop the rollout of the 4th booster for reasons that seemed to imply this as well, but again, I don't have much clarity on that.

ETA: It was a Danish study. Here it is. Make of it as you wish.

The post I quoted suggested the vaccine somehow “ruins” natural immunity, you’re seeing that in the Danish study? I didn’t notice anything about that in the abstract.

[AsherO]

When do I get my second booster?

I don’t think a second booster is on the menu yet.

[CountValentine]

I don’t think a second booster is on the menu yet.

Let me know as I will be the first to order it. 

[as2]

The post I quoted suggested the vaccine somehow “ruins” natural immunity, you’re seeing that in the Danish study? I didn’t notice anything about that in the abstract.

Sorry, my misunderstanding. I think it is saying that the booster lowers vaccine efficiency. Still interesting.

[AsherO]

Let me know as I will be the first to order it. 

I hear you, but you likely aren’t the first one eligible.

[AsherO]

Sorry, my misunderstanding. I think it is saying that the booster lowers vaccine efficiency. Still interesting.

By less than 1%, I’m not sure that’s statistically significant. On the contrary, it suggests a booster accomplishes its purpose.

[Moshe123]

Israel moved up the booster to 3 months after the second dose.

[S209]

The study indicates that a booster is very effective, not that it “ruins” your previous antibodies or any such nonsense.

[AsherO]

The study indicates that a booster is very effective, not that it “ruins” your previous antibodies or any such nonsense.

Interestingly enough the study claimed 2-dose immunity starts to wane after a month, and made no effort to infer the optimal time to boost. It’s also too soon to know how long booster immunity (~55% against Omicron infection) lasts, does that also start to wane after a month?

[as2]

Interestingly enough the study claimed 2-dose immunity starts to wane after a month, and made no effort to infer the optimal time to boost. It’s also too soon to know how long booster immunity (~55% against Omicron infection) lasts, does that also start to wane after a month?

Seems you have significant negative immunity after 90 days if I'm interpreting this right. I'm a bit lost in this study to be quite honest.

[AsherO]

Seems you have significant negative immunity after 90 days if I'm interpreting this right. I'm a bit lost in this study to be quite honest.

I see what you’re asking, but it doesn’t make sense. @biobook any idea what these negative VE numbers mean?

[as2]

I see what you’re asking, but it doesn’t make sense. @biobook any idea what these negative VE numbers mean?

Thanks, I wasn't sure if I was crazy or if it actually seems off. We can always count on @biobook 

[aygart]

When do I get my second booster?

When you go to Israel.

[biobook]

I see what you’re asking, but it doesn’t make sense. @biobook any idea what these negative VE numbers mean?

IDK what a negative VE number means, but here's a simple English report of their recent (non-peer reviewed) paper:
https://www.reuters.com/business/healthcare-pharmaceuticals/significant-increase-protection-vs-omicron-mrna-boosters-study-says-2021-12-22/

[as2]

Found this about the negative numbers. No clue how he got to what he's saying, I just see that's what he's quoting.

https://twitter.com/ezralevant/status/1474106318206255113

[biobook]

Found this about the negative numbers. No clue how he got to what he's saying, I just see that's what he's quoting.

Let's try to find a quote from someone who's an epidemiologist or virologist or immunologist, rather than a journalist who publishes Rebel News.

[aygart]

Let's try to find a quote from someone who's an epidemiologist or virologist or immunologist, rather than a journalist who publishes Rebel News.

Or at least a medical journalist.

[as2]

Let's try to find a quote from someone who's an epidemiologist or virologist or immunologist, rather than a journalist who publishes Rebel News.

Yeesh, I was just sharing what he saw in it because you just said you didn't know what it meant, and he seemed to imply he did. I figured if he made any sense, it might mean something to you. I wasn't giving him any credibility.


Sorry

[biobook]

Ok, I just tried to actually read the paper, and in the discussion they address this question:

"The negative estimates in the final period arguably suggest different behaviour and/or exposure patterns in the vaccinated and unvaccinated cohorts causing underestimation of the VE. This was likely the result of Omicron spreading rapidly initially through single (super-spreading) events causing many infections among young, vaccinated individuals."

So I think they're saying that VE calculation may not be so meaningful in that time period because vaxed were behaving differently, exposing themselves to more large social events, so more likely to get infected than unvaxed.  This sounds like a reasonable speculation to me, but I'm not an epidemiologist etc, so will wait to hear whether the experts buy it.

In any event, they are saying that immunity basically returns with the booster, even if it's short-lasting against Omicron, which might be all we need, since Omicron seems to be short-lasting as an epidemic, so if we can all boost our immunity for another month or so, we may be over it.