So you would use AA miles?
That leaves us to BA, Iberia and Elal and Malev that have a connection in europe.
With the stuff your wife likes, I'd get rid of BA and Iberia (London and Madrid that is).
I'd look for a combination of elal to Europe, and AA to NYC.
If you have a full day, you can try Copenhagen (tivoli, expensive but nice park in center of town) or Amsterdam (surroundings), Zurich (lake and surroundings, cheap boat ride on lake).
You might have to travel via LHR for those destinations, + I did not keep track of the hotels.
Does your wife also like not-natural-scenic-stuff, such as medieval towns, etc.... then you can add Brussels (visit Ghent and or Bruges) .