Obviously the larger the city the greater the job opportunities.
But to say that if you lose your job in a top-25 CSA that you won't find another is pure folly. Sure in Postville, IA that's true. But there are all regions with millions of people and jobs!
1 New York-Newark-Bridgeport, NY-NJ-CT-PA 22,085,649
2 Los Angeles-Long Beach-Riverside, CA 17,877,006
3 Chicago-Naperville-Michigan City, IL-IN-WI 9,686,021
4 Washington-Baltimore-Northern Virginia, DC-MD-VA-WV 8,572,971
5 Boston-Worcester-Manchester, MA-RI-NH 7,559,060
6 San Jose-San Francisco-Oakland, CA 7,468,390
7 Dallas-Fort Worth, TX 6,731,317
8 Philadelphia-Camden-Vineland, PA-NJ-DE-MD 6,533,683
9 Houston-Baytown-Huntsville, TX 6,051,363
10 Atlanta-Sandy Springs-Gainesville, GA-AL 5,618,431
11 Detroit-Warren-Flint, MI 5,218,852
12 Seattle-Tacoma-Olympia, WA 4,199,312
13 Minneapolis-St. Paul-St. Cloud, MN-WI 3,615,902
14 Denver-Aurora-Boulder, CO /1 3,090,874
15 Cleveland-Akron-Elyria, OH 2,881,937
16 St. Louis-St. Charles-Farmington, MO-IL 2,878,255
17 Orlando-Deltona-Daytona Beach, FL 2,818,120
18 Pittsburgh-New Castle, PA 2,447,393
19 Sacramento--Arden-Arcade--Yuba City, CA-NV 2,461,780
20 Charlotte-Gastonia-Salisbury, NC-SC 2,402,623
21 Cincinnati-Middletown-Wilmington, OH-KY-IN 2,172,191
22 Kansas City-Overland Park-Kansas City, MO-KS 2,104,853
23 Indianapolis-Anderson-Columbus, IN 2,080,782
24 Columbus-Marion-Chillicothe, OH 2,071,052
25 Las Vegas-Paradise-Pahrump, NV 1,995,215