I missed the first leg on a return ticket once when flying Turkish Airlines (PRG-IST-PVG). I had decided to take another route back to IST and after speaking with them on the phone, they suggested speaking with their sales office at the airport. The sales rep at the airport was kind enough to let me use just the IST-PVG flight.
Normally the itinerary is voided, but in my case I was lucky enough to be dealing with a really kind rep. I guess you can always try.
EDIT: I should add that my flight to IST was from a different country than Czech Republic and not even with Turkish Airlines.