Might be doable, but isn't it a lot of running all over to things that aren't particularly near each other?
+1
If I were you, I would skip the brewery. I haven't been there, so can't say how great, but it's geographically separated.
You easily do duck tour, USS Constitution (which I love), lunch at Milk Street.
There may be a downtown, say 1:30PM, mincha minyan, but I'm not sure. If you want, I can inquire. Henche probably knows.