You want to see panic just let them try that.
I mean just take a look at the current restrictions, if the restrictions given today, were given a month ago, everyone would panic. Heck, I remember arguing (not so long ago) about Florida not reporting their COVID testing, if it's censorship or is the government rightfully preventing panic. I think you'll agree now how one sided that question seems now. As we get used to the new restrictions it makes it easier to place more and more restrictions.
there are probably thousands of roads and streets connecting many states to each other.
Perhaps it's impossible, but I know China did it successfully. More likely, if there are new local quarantine restrictions, we will see states group up like we did today - NY/NJ/CT.