Is this the first ever ANR-TLV service?
Given that ANR is a very old airport, you'd probably need to check with Antwerp old timers.
Given the issues with the airport, it seems like the E195 is able to serve in a way previously not possible (combination of noise, distance, runway length etc.)
One thing is certain: the route schedule was determined with the target market in mind. I would guess it will be successful (and will have the highest consistent percentage of שומרי שבת of any regularly scheduled commercial route).