the challenge will be to get people to get vaccinated and manage inventory so too many doses don’t go to waste.
Once supply outpaces demand, wasted doses aren't really a problem for the US.
Appointments will help, but I think this will be the real challenge for the Biden administration. It’ll be a massive challenge to get US vaccine confidence anywhere near U.K./Israel levels. As time goes by confidence will go up, but not quickly enough to keep the vaccination pace going until 90%+ of the 16+ population is vaccinated.
There is no way to predict the future, but Israel had very high hesitancy beforehand, but when push comes to shove people end up getting vaccinated.
Over 90% of secular Jews in Israel 16+ got vaccinated. The issue is with the frum and Arab minorities that are at ~70%. The US is far more cohesive and should have less of that problem.
I don't think vaccine hesitancy will be a big deal at the end of the day.